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gluconeogenesis I

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
D-glyceraldehyde_3-phosphate + phosphate + NAD+ <=> 3-phospho-D-glyceroyl_phosphate + NADH + H+ 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
1.2.1.13 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)
1.2.1.59 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating)
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)




D-fructose_1,6-bisphosphate + H2O <=> beta-D-fructose_6-phosphate + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.37 sedoheptulose-bisphosphatase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase




D-fructose_1,6-bisphosphate <=> dihydroxyacetone_phosphate + D-glyceraldehyde_3-phosphate 4.1.2.13 fructose-bisphosphate aldolase
4.1.2.40 tagatose-bisphosphate aldolase


2-phospho-D-glycerate <=> 3-phospho-D-glycerate 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
5.4.2.12 phosphoglycerate mutase (2,3-diphosphoglycerate-independent)


H2O + pyruvate + ATP <=> H+ + phosphate + phosphoenolpyruvate + AMP 2.7.1.40 pyruvate kinase
2.7.9.2 pyruvate, water dikinase


oxaloacetate + ATP <=> CO2 + phosphoenolpyruvate + ADP 4.1.1.31 phosphoenolpyruvate carboxylase
4.1.1.38 phosphoenolpyruvate carboxykinase (diphosphate)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)



(S)-malate + NADP+ <=> pyruvate + CO2 + NADPH 1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.39 malate dehydrogenase (decarboxylating)
1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase




(S)-malate + NAD+ <=> pyruvate + CO2 + NADH 1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.39 malate dehydrogenase (decarboxylating)
1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase
1.3.1.7 meso-tartrate dehydrogenase





D-glucose_6-phosphate <=> beta-D-fructose_6-phosphate 2.6.1.16 glutamine---fructose-6-phosphate transaminase (isomerizing)
5.3.1.8 mannose-6-phosphate isomerase
5.3.1.9 glucose-6-phosphate isomerase



3-phospho-D-glycerate + ATP <=> 3-phospho-D-glyceroyl_phosphate + ADP 2.7.2.10 phosphoglycerate kinase (GTP)
2.7.2.3 phosphoglycerate kinase


(S)-malate + NAD+ <=> oxaloacetate + NADH + H+ 1.1.1.28 D-lactate dehydrogenase
1.1.1.299 malate dehydrogenase [NAD(P)+]
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.81 hydroxypyruvate reductase
1.1.1.82 malate dehydrogenase (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase
1.1.1.95 phosphoglycerate dehydrogenase
1.1.1.96 diiodophenylpyruvate reductase











2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O 4.2.1.11 phosphopyruvate hydratase

D-glyceraldehyde_3-phosphate <=> dihydroxyacetone_phosphate 5.3.1.1 triose-phosphate isomerase

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